Structure of PDB 4ksy Chain A

Receptor sequence
>4ksyA (length=181) Species: 9606 (Homo sapiens) [Search protein sequence]
NFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYIL
LPLDCGVPDNLSMADPNIRFLDKLPQQTGDRAGIKDRVYSNSIYELLENG
QRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILAD
APESQNNCRLIAYQEPSFSLSQEVLRHLRQE
3D structure
PDB4ksy Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING.
ChainA
Resolution1.881 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1SY A S162 Y163 Y167 R238 T263 S11 Y12 Y16 R87 T112 MOAD: Kd=3.79nM
PDBbind-CN: -logKd/Ki=8.42,Kd=3.79nM
Gene Ontology
Biological Process
GO:0002218 activation of innate immune response
GO:0032481 positive regulation of type I interferon production

View graph for
Biological Process
External links
PDB RCSB:4ksy, PDBe:4ksy, PDBj:4ksy
PDBsum4ksy
PubMed23747010
UniProtQ86WV6|STING_HUMAN Stimulator of interferon genes protein (Gene Name=STING1)

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