Structure of PDB 4ks8 Chain A

Receptor sequence
>4ks8A (length=287) Species: 9606 (Homo sapiens) [Search protein sequence]
VTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVA
VKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFL
QGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILL
TLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDI
WSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDF
LERMLVRDPQERATAQELLDHPFLLQTGLPECLVPLI
3D structure
PDB4ks8 Substrate and Inhibitor Specificity of the Type II p21-Activated Kinase, PAK6.
ChainA
Resolution1.95 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D526 K528 D530 S531 D544 K553 T564
Catalytic site (residue number reindexed from 1) D142 K144 D146 S147 D160 K169 T180
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 B49 A I413 A434 M481 E482 F483 L484 G487 L533 S543 I29 A50 M97 E98 F99 L100 G103 L149 S159 BindingDB: Kd=2400nM,Ki=500nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4ks8, PDBe:4ks8, PDBj:4ks8
PDBsum4ks8
PubMed24204982
UniProtQ9NQU5|PAK6_HUMAN Serine/threonine-protein kinase PAK 6 (Gene Name=PAK6)

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