Structure of PDB 4kre Chain A

Receptor sequence
>4kreA (length=799) Species: 9606 (Homo sapiens) [Search protein sequence]
QQVFQAPRRPGIGTVGKPIKLLANYFEVDIPKIDVYHYEVDIKPDKCPRR
VNREVVEYMVQHFKIFGDRKPVYDGKKNIYTVTALPIGERVDFEVTRIFK
VSIKWLAIVSWRMLHEALVSGQIPVPLESVQALDVAMRHLASMRYTPVGR
SFFSPPEGYYHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQP
VIEFMCEVLDIRQPKPLTDSQRVRFTKEIKGLKVEVTHCGKRKYRVCNVT
RRPASHQTFPLQLESGQTVECTVAQYFKQKYNLQLKYPHLPCLQVGHTYL
PLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLMKNASYN
LDPYIQEFGIKVKDDMTEVTGRVLPAPILQYGGRNRAIATPNQGVWDMRG
KQFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQLRKISKDAGMPIQGQP
CFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTL
LGMATQCVQVKNVVKTSPQTLSNLCLKINVKLGGINNILVPHQRSAVFQQ
PVIFLGADVTHPPKKPSITAVVGSMDAHPSRYCATVRVQRPRQEIIEDLS
YMVRELLIQFYKSTRFKPTRIIFYRDGVPEGQLPQILHYELLAIRDACIK
LEKDYQPGITYIVVQKRHHTRLFCADKNERIGKSGNIPAGTTVDTNITHP
FEFDFYLCSHAGIQGTSRPSHYYVLWDDNRFTADELQILTYQLCHTYVRC
TRSVSIPAPAYYARLVAFRARYHLVDRDPQALAKAVQVHQDTLRTMYFA
3D structure
PDB4kre The making of a slicer: activation of human argonaute-1.
ChainA
Resolution1.754 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Gene Ontology
Molecular Function
GO:0000993 RNA polymerase II complex binding
GO:0001046 core promoter sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0003727 single-stranded RNA binding
GO:0004521 RNA endonuclease activity
GO:0005515 protein binding
GO:0035198 miRNA binding
GO:0061980 regulatory RNA binding
Biological Process
GO:0000956 nuclear-transcribed mRNA catabolic process
GO:0006417 regulation of translation
GO:0010501 RNA secondary structure unwinding
GO:0016525 negative regulation of angiogenesis
GO:0031047 regulatory ncRNA-mediated gene silencing
GO:0031054 pre-miRNA processing
GO:0035194 regulatory ncRNA-mediated post-transcriptional gene silencing
GO:0035196 miRNA processing
GO:0035278 miRNA-mediated gene silencing by inhibition of translation
GO:0035279 miRNA-mediated gene silencing by mRNA destabilization
GO:0043488 regulation of mRNA stability
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0070922 RISC complex assembly
GO:0090625 siRNA-mediated gene silencing by mRNA destabilization
Cellular Component
GO:0000932 P-body
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016442 RISC complex
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0043232 intracellular non-membrane-bounded organelle
GO:0070578 RISC-loading complex
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4kre, PDBe:4kre, PDBj:4kre
PDBsum4kre
PubMed23746446
UniProtQ9UL18|AGO1_HUMAN Protein argonaute-1 (Gene Name=AGO1)

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