Structure of PDB 4kqr Chain A

Receptor sequence
>4kqrA (length=520) Species: 208964 (Pseudomonas aeruginosa PAO1) [Search protein sequence]
RSVRHIAIPAHRGLITDRNGEPLAVSTPVTTLWANPKELMTAKERWPQLA
AALGQDTKLFADRIEQNAEREFIYLVRGLTPEQGEGVIALKVPGVYSIEE
FRRFYPAGEVVAHAVGFTDVDDRGREGIELAFDEWLAGVPGKRQVLKDRR
GRVIKDVQVTKNAKPGKTLALSIDLRLQYLAHRELRNALLENGAKAGSLV
IMDVKTGEILAMTNQPTYNPNNRRNLQPAAMRNRAMIDVFEPGSTVKPFS
MSAALASGRWKPSDIVDVYPGTLQIGRYTIRDVSRNSRQLDLTGILIKSS
NVGISKIAFDIGAESIYSVMQQVGLGQDTGLGFPGERVGNLPNHRKWPKA
ETATLAYGYGLSVTAIQLAHAYAALANDGKSVPLSMTRVDRVPDGVQVIS
PEVASTVQGMLQQVVEAQGGVFRAQVPGYHAAGKSGTARKVSVGTKGYRE
NAYRSLFAGFAPATDPRIAMVVVIDEPSKAGYFGGLVSAPVFSKVMAGAL
RLMNVPPDNLPTATEQQQVN
3D structure
PDB4kqr Binding of (5S)-Penicilloic Acid to Penicillin Binding Protein 3.
ChainA
Resolution2.01 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.16.4: serine-type D-Ala-D-Ala carboxypeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VPP A S294 V333 S349 Y407 Y409 S485 G486 T487 R489 Y498 Y503 F533 G534 G535 S244 V283 S299 Y357 Y359 S435 G436 T437 R439 Y448 Y453 F483 G484 G485 MOAD: ic50=126uM
PDBbind-CN: -logKd/Ki=3.90,IC50=126uM
Gene Ontology
Molecular Function
GO:0004180 carboxypeptidase activity
GO:0008658 penicillin binding
GO:0008955 peptidoglycan glycosyltransferase activity
GO:0009002 serine-type D-Ala-D-Ala carboxypeptidase activity
Biological Process
GO:0000917 division septum assembly
GO:0006508 proteolysis
GO:0008360 regulation of cell shape
GO:0009252 peptidoglycan biosynthetic process
GO:0043093 FtsZ-dependent cytokinesis
GO:0051301 cell division
GO:0071555 cell wall organization
Cellular Component
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4kqr, PDBe:4kqr, PDBj:4kqr
PDBsum4kqr
PubMed23899657
UniProtG3XD46|FTSI_PSEAE Peptidoglycan D,D-transpeptidase FtsI (Gene Name=ftsI)

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