Structure of PDB 4kn0 Chain A

Receptor sequence
>4kn0A (length=205) Species: 9606 (Homo sapiens) [Search protein sequence]
RTDLLNVCMDAKHHKTKPGPEDKLHDQCSPWKKNACCTASTSQELHKDTS
RLYNFNWDHCGKMEPACKRHFIQDTCLYECSPNLGPWIQQVNQSWRKERF
LDVPLCKEDCQRWWEDCHTSHTCKSNWHRGWDWTSGVNKCPAGALCRTFE
SYFPTPAALCEGLWSHSYKVSNYSRGSGRCIQMWFDSAQGNPNEEVARFY
AAAMH
3D structure
PDB4kn0 Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition.
ChainA
Resolution2.1 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MTX A Y76 F78 Y101 Q116 W118 H151 R152 G153 W154 W156 W187 S190 Y53 F55 Y78 Q93 W95 H128 R129 G130 W131 W133 W164 S167 MOAD: Kd=40nM
PDBbind-CN: -logKd/Ki=7.40,Kd=40nM
BindingDB: IC50=106nM
External links
PDB RCSB:4kn0, PDBe:4kn0, PDBj:4kn0
PDBsum4kn0
PubMed23934049
UniProtP14207|FOLR2_HUMAN Folate receptor beta (Gene Name=FOLR2)

[Back to BioLiP]