Structure of PDB 4kis Chain A

Receptor sequence

>4kisA (length=315) Species: 272626 (Listeria innocua Clip11262) [Search protein sequence]

DRMVMGKIKRIEAGLPLTTAKGRTFGYDVIDTKLYINEEEAKQLRLIYDI
FEEEQSITFLQKRLKKLGFKVRTYNRYNNWLTNDLYCGYVSYKDKVHVKG
IHEPIISEEQFYRVQEIFSRMGKNPNMNKESASLLNNLVVCSKCGLGFVH
RRKDTVSRGKKYHYRYYSCKTYKHTHELEKCGNKIWRADKLEELIIDRVN
NYSFASRNIDKEDESLNEKLKIEHAKKKRLFDLYINGSYEVSELDSMMND
IDAQINYYEAQIEANEELKKNKTVDFNSLEFREKQLYLKSLINKIYIDGE
QVTIEWLLEHHHHHH

3D structure

PDB

4kis Attachment site recognition and regulation of directionality by the serine integrases.

Chain

Resolution

3.2 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	R135 M136 G139 K140 R143 A153 K154 R156 S189 T191 Y207 M254 N261 K262 K286 S290 R291 Y295 Y297 Y299 H309	R2 M3 G6 K7 R10 A20 K21 R23 S56 T58 Y74 M121 N128 K129 K153 S157 R158 Y162 Y164 Y166 H176	PDBbind-CN: Kd~20nM
BS02	dna	A	M136 R209 N212 Y225 K226 N259 S264 S266 N269 H283 R285 T288 K303 K306	M3 R76 N79 Y92 K93 N126 S131 S133 N136 H150 R152 T155 K170 K173	PDBbind-CN: Kd~20nM
BS03	ZN	A	C274 K276 C302 C314	C141 K143 C169 C181
BS04	ZN	A	H455 H457 H459	H310 H312 H314
BS05	ZN	A	H458 H460	H313 H315

Gene Ontology

	Molecular Function
GO:0000150	DNA strand exchange activity
GO:0003677	DNA binding

View graph for
Molecular Function

External links

PDB	RCSB:4kis, PDBe:4kis, PDBj:4kis
PDBsum	4kis
PubMed	23821671
UniProt	Q928V6

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