Structure of PDB 4kik Chain A

Receptor sequence
>4kikA (length=619) Species: 9606 (Homo sapiens) [Search protein sequence]
TQTCGAWEMKERLGTGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLE
IQIMRRLTHPNVVAARDVPEGMQNDLPLLAMEYCQGGDLRKYLNQFENCC
GLREGAILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKII
DLGYTSFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPN
WQPVQWHSKVRQKSEVDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEK
WLQLMLMWHPRQRGTDPTYGPNGCFKALDDILNLKLVHILNMVTGTIHTY
PVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLALIPDKPATQCISLNE
GHTLDMDLVFLFDNSKITYETQRPQPESVSCILQEPKRNLAFFQLRKVWG
QVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLKA
KLDFFKTSIQIDLEKYSEQTDKLLLAWREMEQAVELCGRENEVKLLVERM
MALQTDIVDLQRSGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLL
LQAIQSFEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVV
RLQEKRQKELWNLLKIACS
3D structure
PDB4kik Crystal Structure of a Human I kappa B Kinase beta Asymmetric Dimer.
ChainA
Resolution2.83 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D145 K147 E149 N150 D166 T185
Catalytic site (residue number reindexed from 1) D130 K132 E134 N135 D151 T160
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
2.7.11.10: IkappaB kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KSA A L21 G22 V29 A42 K44 M96 Y98 G102 E149 I165 L13 G14 V18 A31 K33 M81 Y83 G87 E134 I150
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4kik, PDBe:4kik, PDBj:4kik
PDBsum4kik
PubMed23792959
UniProtO14920|IKKB_HUMAN Inhibitor of nuclear factor kappa-B kinase subunit beta (Gene Name=IKBKB)

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