Structure of PDB 4kh4 Chain A

Receptor sequence
>4kh4A (length=592) Species: 5811 (Toxoplasma gondii) [Search protein sequence]
DADTEKRINVGKTHLQTLRNLETRCHDSLQALVVIDAGSSSTRTNVFLAK
TRSCPNKGRSIDPDSIQLIREGKRFTGLRVVLEEWLDTYAGKDWESRPVD
ARLLFQYVPQMHEGAKKLMQLLEEDTVAILDSQLNEEQKVQVKALGIPVM
LCSTAGVRDFHEWYRDALFVLLRHLINNPSPAHGYKFFTNPFWTRPITGA
EEGLFAFITLNHLSRRLGEDPARSMIDEYGVKHSRNDLAGVVEVGGASAQ
IVFPLQEGTVLPSSVRAVNLQRERLLPERYPSADVVSVSFMQLGMASSAG
LFLKELCSNDEFLQGGICSNPCLFKGFQQSCSAGEVEVRPDGSASVNEDV
RKNRLKPLATYCSVHNPEISFKVTNEMQCRENSIDPTKPLAERMKIENCS
IIEGTGNFDKCVSQVESILVAPKLPLPANIEAASSGFESVDQVFRFASST
APMFITGREMLASIDTLKDHRLLRSDFSGDVEELAEAAREFCSSEVIIRT
DGPVIQLPGEQKLNSLNFDLCKTMALTVSLLRHMAAGENQPSFIKWEKSI
AGPDGKPLADLGWQVGVILHHVLFTEEWGRTAYEAGYSHNLE
3D structure
PDB4kh4 The ATP/ADP substrate specificity switch between Toxoplasma gondii NTPDase1 and NTPDase3 is caused by an altered mode of binding of the substrate base.
ChainA
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.15: nucleoside-triphosphate phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP A G72 S73 S74 R77 R108 T188 A189 G279 G280 S282 G38 S39 S40 R43 R74 T154 A155 G245 G246 S248
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0017111 ribonucleoside triphosphate phosphatase activity
Cellular Component
GO:0005576 extracellular region
GO:0020003 symbiont-containing vacuole

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Molecular Function
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Cellular Component
External links
PDB RCSB:4kh4, PDBe:4kh4, PDBj:4kh4
PDBsum4kh4
PubMed24115522
UniProtQ27895|NTP2_TOXGO Nucleoside-triphosphatase 2 (Gene Name=NTP1)

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