Structure of PDB 4kh2 Chain A

Receptor sequence
>4kh2A (length=595) Species: 9606 (Homo sapiens) [Search protein sequence]
APHLVQVDAARALWPLRRFWRSTGFCPPYVLSWDQQLNLAYVGAVPHRGI
KQVRTHWLLELVTTLSYNFTHLDGYLDLLRENQLLPGFELMGSASGHFTD
FEDKQQVFEWKDLVSSLARRYIGRYGLAHVSKWNFETWNEPDHHDFDNVS
MTMQGFLNYYDACSEGLRAASPALRLGGPGDSFHTPPRSPLSWGLLRHCH
DGTNFFTGEAGVRLDYISLHRKGARSSISILEQEKVVAQQIRQLFPKFAD
TPIYNDEADPLVGWSLPQPWRADVTYAAMVVKVIAQHQNLLLANTTSAFP
YALLSNDNAFLSYHPHPFAQRTLTARFQVNNTRPPHVQLLRKPVLTAMGL
LALLDEEQLWAEVSQAGTVLDSNHTVGVLASAHRPQGPADAWRAAVLIYA
SDDTRAHPNRSVAVTLRLRGVPPGPGLVYVTRYLDNGLCSPDGEWRRLGR
PVFPTAEQFRRMRAAEDPVAAAPRPLPAGGRLTLRPALRLPSLLLVHVCA
RPEKPPGQVTRLRALPLTQGQLVLVWSDEHVGSKCLWTYEIQFSQDYTPV
SRKPSTFNLFVFSPDTGAVSGSYRVRALDYWARPGPFSDPVPYLE
3D structure
PDB4kh2 Insights into mucopolysaccharidosis I from the structure and action of alpha-L-iduronidase.
ChainA
Resolution2.36 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.76: L-iduronidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FIF A H91 N181 K264 E299 G305 W306 D349 R363 H56 N139 K222 E257 G263 W264 D307 R321
Gene Ontology
Molecular Function
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
Biological Process
GO:0005975 carbohydrate metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4kh2, PDBe:4kh2, PDBj:4kh2
PDBsum4kh2
PubMed24036510
UniProtP35475|IDUA_HUMAN Alpha-L-iduronidase (Gene Name=IDUA)

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