Structure of PDB 4kga Chain A

Receptor sequence
>4kgaA (length=221) Species: 9606 (Homo sapiens) [Search protein sequence]
IINGEDCSPHSQPWQAALVMENELFCSGVLVHPQWVLSAAHCFQNSYTIG
LGLHSLEQEPGSQMVEASLSVRHPEYNRPLLANDLMLIKLDESVSESDTI
RSISIASQCPTAGNSCLVSGWGLLANGRMPTVLQCVNVSVVSEEVCSKLY
DPLYHPSMFCAGGGQDQKDSCNGDSGGPLICNGYLQGLVSFGKAPCGQVG
VPGVYTNLCKFTEWIEKTVQA
3D structure
PDB4kga Direct and indirect mechanisms of KLK4 inhibition revealed by structure and dynamics
ChainA
Resolution2.32 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 N192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H41 D84 N172 G173 D174 S175 G176
Enzyme Commision number 3.4.21.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NI A H25 E77 H10 E59
BS02 NI A H57 S195 H41 S175
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0008236 serine-type peptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0022617 extracellular matrix disassembly
GO:0031214 biomineral tissue development
GO:0097186 amelogenesis
Cellular Component
GO:0005576 extracellular region
GO:0030141 secretory granule

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Cellular Component
External links
PDB RCSB:4kga, PDBe:4kga, PDBj:4kga
PDBsum4kga
PubMed27767076
UniProtQ9Y5K2|KLK4_HUMAN Kallikrein-4 (Gene Name=KLK4)

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