Structure of PDB 4kbz Chain A

Receptor sequence
>4kbzA (length=231) Species: 9606 (Homo sapiens) [Search protein sequence]
TKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGK
FTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCN
GKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDW
DAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRY
AITVWYFDADERARAKVKYEKGLRVELNKPS
3D structure
PDB4kbz ?
ChainA
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.29: hypoxia-inducible factor-proline dioxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1QA A R252 W258 M299 Y303 Y310 H313 D315 R322 I327 L343 H374 V376 R383 W389 K408 R68 W74 M115 Y119 Y126 H129 D131 R138 I143 L159 H190 V192 R199 W205 K221 BindingDB: IC50=2800nM
BS02 FE2 A H313 D315 H374 H129 D131 H190
Gene Ontology
Molecular Function
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0031418 L-ascorbic acid binding

View graph for
Molecular Function
External links
PDB RCSB:4kbz, PDBe:4kbz, PDBj:4kbz
PDBsum4kbz
PubMed
UniProtQ9GZT9|EGLN1_HUMAN Egl nine homolog 1 (Gene Name=EGLN1)

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