Structure of PDB 4kbl Chain A

Receptor sequence
>4kblA (length=395) Species: 9606 (Homo sapiens) [Search protein sequence]
YRYEVLTAEQILQHMVECIREVNEVIQNPATITRILLSHFNWDKEKLMER
YFDGNMPCQICYLNYPNSYFTGLECGHKFCMQCWSEYLTTKIMEEGMGQT
ISCPAHGCDILVDDNTVMRLITDSKVKLKYQHLITNSFVECNRLLKWCPA
PDCHHVVKVQYPDAKPVRCKCGRQFCFNCGENWHDPVKCKWLKKWIKKCI
AANTKECPKCHVTIEKDGGCNHMVCRNQNCKAEFCWVCLGPWEPHGSAWY
NCNRYNRSRAALQRYLFYCNRYMNHMQSLRFEHKLYAQVKQKMEWIEVQF
LKKAVDVLCQCRATLMYTYVFAFYLKKNNQSIIFENNQADLENATEVLSG
YLERDISQDSLQDIKQKVQDKYRYCESRRRVLLQHVHEGYEKDLW
3D structure
PDB4kbl Structure of HHARI, a RING-IBR-RING Ubiquitin Ligase: Autoinhibition of an Ariadne-Family E3 and Insights into Ligation Mechanism.
ChainA
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.31: RBR-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C344 C347 C362 C207 C210 C225
BS02 ZN A C372 C375 H382 C389 C235 C238 H245 C252
BS03 ZN A C276 C281 C297 C299 C148 C153 C169 C171
BS04 ZN A C304 C307 H312 C176 C179 H184
BS05 ZN A C186 C189 C211 C58 C61 C83
BS06 ZN A C203 H205 C231 C75 H77 C103
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016740 transferase activity
GO:0019787 ubiquitin-like protein transferase activity
GO:0031624 ubiquitin conjugating enzyme binding
GO:0031625 ubiquitin protein ligase binding
GO:0046872 metal ion binding
GO:0061630 ubiquitin protein ligase activity
Biological Process
GO:0000209 protein polyubiquitination
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016567 protein ubiquitination
GO:0039585 PKR/eIFalpha signaling
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0015030 Cajal body
GO:0016604 nuclear body
GO:0019005 SCF ubiquitin ligase complex
GO:0031462 Cul2-RING ubiquitin ligase complex
GO:0031463 Cul3-RING ubiquitin ligase complex
GO:0031464 Cul4A-RING E3 ubiquitin ligase complex
GO:0097413 Lewy body

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4kbl, PDBe:4kbl, PDBj:4kbl
PDBsum4kbl
PubMed23707686
UniProtQ9Y4X5|ARI1_HUMAN E3 ubiquitin-protein ligase ARIH1 (Gene Name=ARIH1)

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