Structure of PDB 4kbk Chain A

Receptor sequence
>4kbkA (length=283) Species: 9606 (Homo sapiens) [Search protein sequence]
LRVGNRYRLGRKIGSGGDIYLGTDIAAGEEVAIKLECQLHIESKIYKMMQ
GGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLAD
QMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDAR
THQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGS
LPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRF
DDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNML
3D structure
PDB4kbk Ligand-protein interactions of selective casein kinase 1 delta inhibitors.
ChainA
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D128 K130
Catalytic site (residue number reindexed from 1) D118 K120
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
2.7.11.26: [tau protein] kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1QG A I15 I23 A36 K38 M80 M82 L85 G86 L135 I148 I13 I19 A32 K34 M70 M72 L75 G76 L125 I138 PDBbind-CN: -logKd/Ki=8.18,IC50=6.6nM
BindingDB: IC50=6.6nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4kbk, PDBe:4kbk, PDBj:4kbk
PDBsum4kbk
PubMed23919824
UniProtP48730|KC1D_HUMAN Casein kinase I isoform delta (Gene Name=CSNK1D)

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