Structure of PDB 4kbb Chain A

Receptor sequence

>4kbbA (length=417) Species: 1491 (Clostridium botulinum) [Search protein sequence]

NNIILNLRYKDNNLIDLSGYGAKVEVYDGVELNDKNQFKLTSSANSKIRV
TQNQNIIFNSVFLDFSVSFWIRIPKYKNDGIQNYIHNEYTIINCMKNNSG
WKISIRGNRIIWTLIDINGKTKSVFFEYNIREDISEYINRWFFVTITNNL
NNAKIYINGKLESNTDIKDIREVIANGEIIFKLDGDIDRTQFIWMKYFSI
FNTELSQSNIEERYKIQSYSEYLKDFWGNPLMYNKEYYMFNAGNKNSYIK
LKKDSPVGEILTRSKYNQNSKYINYRDLYIGEKFIIRRKSDIVRKEDYIY
LDFFNLNQEWRVYTYKYFKKEEEKLFLAPISDSDEFYNTIQIKEYDEQPT
YSCQLLFKKDEESTDEIGLIGIHRFYEEYKDYFCISKWYLKEVKRKPYNL
KLGCNWQFIPKDEGWTE

3D structure

PDB

4kbb Structure of dual receptor binding to botulinum neurotoxin B.

Chain

Resolution

2.3 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	Q898 R967
Catalytic site (residue number reindexed from 1)	Q37 R106
Enzyme Commision number	3.4.24.69: bontoxilysin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	A	D1115 P1117 V1118 Y1183 E1191 K1192 F1194 P1197 S1199 F1204	D254 P256 V257 Y315 E323 K324 F326 P329 S331 F336
BS02	GAL	A	E1190 I1240 H1241 S1260 W1262 Y1263	E322 I372 H373 S386 W388 Y389
BS03	SIA	A	G1104 N1105 Y1263 K1275 G1277	G243 N244 Y389 K401 G403
BS04	BGC	A	S984 V985 F986 T1026	S123 V124 F125 T165

Gene Ontology

	Cellular Component
GO:0005576	extracellular region

View graph for
Cellular Component

External links

PDB	RCSB:4kbb, PDBe:4kbb, PDBj:4kbb
PDBsum	4kbb
PubMed	23807078
UniProt	P10844\|BXB_CLOBO Botulinum neurotoxin type B (Gene Name=botB)

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