Structure of PDB 4kb6 Chain A

Receptor sequence

>4kb6A (length=353) Species: 9823 (Sus scrofa) [Search protein sequence]

GAWKLQTVLEKVRLSRHEISEAAEVVNWVVEHLLRRLQGGESEFKGVALL
RTGSYYERVKISAPNQFNVMFKLEVPRIQLEEYCNSGAHYFVKFPLEQFL
EKEILSASKMLSKFRKIIKEEIKNIEDTGVTVERKRRGSPAVTLLISKPK
EISVDIILALESKSSWPASTQKGLPISQWLGAKVKNNLKRQPFYLVPKHA
KGFQEETWRLSFSHIEKDILKNHGQSKTCCEIDGVKCCRKECLKLMKYLL
EQLKKKFGNRRELAKFCSYHVKTAFFHVCTQDPHDNQWHLKNLECCFDNC
VAYFLQCLKTEQLANYFIPGVNLFSRDLIDKPSKEFLSKQIEYERNNGFP
VFW

3D structure

PDB

4kb6 Structural mechanism of cytosolic DNA sensing by cGAS.

Chain

Resolution

3.0754 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.7.86: cyclic GMP-AMP synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	R147 L148 R150 R192 K384	R13 L14 R16 R58 K240
BS02	dna	A	R150 S154 R185 Y189 K361	R16 S20 R51 Y55 K217
BS03	ZN	A	H367 C374 C381	H223 C230 C237
BS04	GTP	A	M204 G279 S280 P281 D296 I298 R353 S355 S357	M70 G138 S139 P140 D155 I157 R209 S211 S213
BS05	ATP	A	G187 S188 N202 R353 S357 E360 K391 S412 Y413	G53 S54 N68 R209 S213 E216 K247 S268 Y269
BS06	MG	A	S188 Q200 N202	S54 Q66 N68

External links

PDB	RCSB:4kb6, PDBe:4kb6, PDBj:4kb6
PDBsum	4kb6
PubMed	23722159
UniProt	I3LM39\|CGAS_PIG Cyclic GMP-AMP synthase (Gene Name=CGAS)

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