Structure of PDB 4kat Chain A

Receptor sequence
>4katA (length=218) Species: 243274 (Thermotoga maritima MSB8) [Search protein sequence]
HHMKIDILDKGFVELVDVMGNDLSAVRAARVSFDMGLKDEERDRHLIEYL
MKHGHETPFEHIVFTFHVKAPIFVARQWFRHRIASYNELSGRYSKLSYEF
YIPSPERLEGYKTTIPPERVTEKISEIVDKAYRTYLELIESGVPREVARI
VLPLNLYTRFFWTVNARSLMNFLNLKADSHAQWEIQQYALAIARIFKEKC
PWTFEAFLKYAYKGDILK
3D structure
PDB4kat Flavin-Dependent Thymidylate Synthase as a Drug Target for Deadly Microbes: Mutational Study and a Strategy for Inhibitor Design.
ChainA
Resolution2.14 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.1.1.148: thymidylate synthase (FAD).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DU A E86 S88 G89 R90 R147 E88 S90 G91 R92 R149
BS02 FDA A R78 H79 R80 I81 N169 L173 H178 R80 H81 R82 I83 N171 L175 H180
BS03 FDA A S30 T55 E58 I81 N163 R165 S32 T57 E60 I83 N165 R167
BS04 FDA A N85 E86 N87 E88
BS05 DU A Q75 R78 K174 Q77 R80 K176
Gene Ontology
Molecular Function
GO:0004799 thymidylate synthase activity
GO:0008168 methyltransferase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0050797 thymidylate synthase (FAD) activity
GO:0070402 NADPH binding
Biological Process
GO:0006231 dTMP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0032259 methylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4kat, PDBe:4kat, PDBj:4kat
PDBsum4kat
PubMed24563811
UniProtQ9WYT0|THYX_THEMA Flavin-dependent thymidylate synthase (Gene Name=thyX)

[Back to BioLiP]