Structure of PDB 4k9y Chain A

Receptor sequence
>4k9yA (length=271) Species: 9606 (Homo sapiens) [Search protein sequence]
YEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSV
REKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVR
KYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGD
FGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWE
ILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPS
RRPRFTELKAQLSTILEEEKA
3D structure
PDB4k9y Fragment-based discovery of focal adhesion kinase inhibitors.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D546 A548 R550 N551 D564 K583
Catalytic site (residue number reindexed from 1) D132 A134 R136 N137 D150 K169
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 K9Y A I428 A452 E471 M475 V484 M499 C502 F542 L553 G563 D564 F565 R569 Y570 I14 A38 E57 M61 V70 M85 C88 F128 L139 G149 D150 F151 R155 Y156 MOAD: Kd=0.111uM
PDBbind-CN: -logKd/Ki=6.95,Kd=0.111uM
BindingDB: Kd=111nM,IC50=750nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4k9y, PDBe:4k9y, PDBj:4k9y
PDBsum4k9y
PubMed23973211
UniProtQ05397|FAK1_HUMAN Focal adhesion kinase 1 (Gene Name=PTK2)

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