Structure of PDB 4k9b Chain A

Receptor sequence
>4k9bA (length=355) Species: 10090 (Mus musculus) [Search protein sequence]
KLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNTG
SYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFKRGNPLSHF
LEGEVLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRNP
EEISVDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPKN
AKDGNSFQGETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECLKLM
KYLLEQLKKEFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDK
LLAFFLECLRTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNGF
PIFDK
3D structure
PDB4k9b Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase.
ChainA
Resolution2.26 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.7.86: cyclic GMP-AMP synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A R158 L159 K160 R161 E386 K395 R10 L11 K12 R13 E235 K244
BS02 dna A S165 N196 Y200 Y201 K372 S17 N48 Y52 Y53 K221
BS03 ZN A H378 C384 C385 C392 H227 C233 C234 C241
BS04 G A G290 S291 P292 D307 I309 K350 R364 G139 S140 P141 D156 I158 K199 R213
BS05 A A R364 C419 Y421 R213 C268 Y270
External links
PDB RCSB:4k9b, PDBe:4k9b, PDBj:4k9b
PDBsum4k9b
PubMed23647843
UniProtQ8C6L5|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)

[Back to BioLiP]