Structure of PDB 4k9a Chain A

Receptor sequence
>4k9aA (length=354) Species: 10090 (Mus musculus) [Search protein sequence]
KLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNTG
SYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFKGNPLSHFL
EGEVLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRNPE
EISVDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPKNA
KDGNSFQGETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECLKLMK
YLLEQLKKEFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDKL
LAFFLECLRTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNGFP
IFDK
3D structure
PDB4k9a Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase.
ChainA
Resolution2.264 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.86: cyclic GMP-AMP synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A R158 L159 K160 R161 R180 E386 K395 R10 L11 K12 R13 R32 E234 K243
BS02 dna A R161 S165 A168 N196 Y200 K372 R13 S17 A20 N48 Y52 K220
BS03 ZN A H378 C384 C385 C392 H226 C232 C233 C240
BS04 G A D213 C419 S420 Y421 D65 C267 S268 Y269
BS05 A A D213 D307 I309 K350 S366 D65 D155 I157 K198 S214
External links
PDB RCSB:4k9a, PDBe:4k9a, PDBj:4k9a
PDBsum4k9a
PubMed23647843
UniProtQ8C6L5|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)

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