Structure of PDB 4k97 Chain A

Receptor sequence

>4k97A (length=351) Species: 10090 (Mus musculus) [Search protein sequence]

KLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNTG
SYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFKPLSHFLEG
EVLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRNPEEI
SVDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPKNAKD
GNSFQGETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECLKLMKYL
LEQLKKEFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDKLLA
FFLECLRTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNGFPIF
D

3D structure

PDB

4k97 Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase.

Chain

Resolution

2.41 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.7.86: cyclic GMP-AMP synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	R158 L159 K160 R161 R180 H203 N376 K395	R10 L11 K12 R13 R32 H55 N222 K241
BS02	dna	A	R161 S165 N196 Y200 K372	R13 S17 N48 Y52 K218
BS03	ZN	A	H378 C384 C385 C392	H224 C230 C231 C238
BS04	MG	A	E211 D213 D307	E63 D65 D153
BS05	MG	A	E211 D213	E63 D65
BS06	ATP	A	S199 E211 D213 R364 E371 K402 S420 Y421	S51 E63 D65 R210 E217 K248 S266 Y267

External links

PDB	RCSB:4k97, PDBe:4k97, PDBj:4k97
PDBsum	4k97
PubMed	23647843
UniProt	Q8C6L5\|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)

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