Structure of PDB 4k90 Chain A

Receptor sequence
>4k90A (length=389) Species: 330879 (Aspergillus fumigatus Af293) [Search protein sequence]
ADYQVYAWGINDPTEGERTVIKDPWDSVASEFTWISDGSTNYTTSRGNNG
IAQSNPSGGPSYLNNYRPSSSSLSFKYPYSVSSSPPSSYIDASIIQLFYT
ANIYHDLLYTLGFTEKAGNFEYNTNGQGGLGNDYVILNAQDGSGTNNANF
ATPPDGQPGRMRMYVWTESTPYRDGSFEAGIVIHEYTHGLSNRLTGGPAN
SNCLNALESGGMGEGWSDFMATAIRLKPGDKRSTDYTMGEWASNRAGGIR
QYPYSTSLSTNPLTYTSVNSLNAVHAIGTVWASMLYEVLWNLIDKHGKND
APKPTLRDGVPTDGKYLAMKLVMDGMALQPCNPNFVQARDAILDADTALT
GGENQCEIWTAFAKRGLGAGAKYSSRNRVGSTEVPSGVC
3D structure
PDB4k90 A functional and structural study of the major metalloprotease secreted by the pathogenic fungus Aspergillus fumigatus.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H429 H433 E459 H184 H188 E214
BS02 CA A N364 L375 D378 D400 N119 L130 D133 D155
BS03 CA A N437 R438 T440 G442 N445 N192 R193 T195 G197 N200
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008270 zinc ion binding
Cellular Component
GO:0005615 extracellular space

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Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:4k90, PDBe:4k90, PDBj:4k90
PDBsum4k90
PubMed24100314
UniProtP46075|ELM_ASPFU Extracellular metalloproteinase mep (Gene Name=mep)

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