Structure of PDB 4k7a Chain A

Receptor sequence
>4k7aA (length=242) Species: 9606 (Homo sapiens) [Search protein sequence]
QPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWA
KALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSAMLYFAPDLV
FNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVD
GLKNQKFFDELRMNYIKELDRIIASCSRRFYQLTKLLDSVQPIARELHQF
TFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT
3D structure
PDB4k7a Crystal structure of the androgen receptor ligand binding domain in complex with minoxidil
ChainA
Resolution2.44 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DHT A L704 N705 L707 Q711 M745 T877 L35 N36 L38 Q42 M76 T201 BindingDB: IC50=>10000nM,EC50=6nM,Ki=0.2nM
BS02 MXD A E793 W796 E124 W127
External links
PDB RCSB:4k7a, PDBe:4k7a, PDBj:4k7a
PDBsum4k7a
PubMed
UniProtP10275|ANDR_HUMAN Androgen receptor (Gene Name=AR)

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