Structure of PDB 4k6w Chain A

Receptor sequence
>4k6wA (length=183) Species: 52275 (Human adenovirus D37) [Search protein sequence]
TRTLWTTPDTSPNCTIAQDKDSKLTLVLTKCGSQILANVSLIVVAGKYHI
INNKTNPKIKSFTIKLLFNKNGVLLDNSNLGKAYWNFRSGNSNVSTAYEK
AIGFMPNLVAYPKPSNSKKYARDIVYGTIYLGGKPDQPAVIKTTFNQETG
CEYSITFNFSWSKTYENVEFETTSFTFSYIAQE
3D structure
PDB4k6w Triazole linker-based trivalent sialic acid inhibitors of adenovirus type 37 infection of human corneal epithelial cells.
ChainA
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 18D A Y312 P317 D318 K345 Y130 P135 D136 K163 PDBbind-CN: -logKd/Ki=5.35,IC50=4.5uM
BS02 ZN A H231 E351 H49 E169
Gene Ontology
Biological Process
GO:0007155 cell adhesion
GO:0019058 viral life cycle
GO:0019062 virion attachment to host cell
Cellular Component
GO:0019028 viral capsid

View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4k6w, PDBe:4k6w, PDBj:4k6w
PDBsum4k6w
PubMed26177934
UniProtQ64823

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