Structure of PDB 4k6i Chain A

Receptor sequence
>4k6iA (length=214) Species: 9606 (Homo sapiens) [Search protein sequence]
EDMPVERILEAELAVEPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPL
DDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGA
IFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALRE
KVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGD
TPIDTFLMEMLEAP
3D structure
PDB4k6i Defining the Communication between Agonist and Coactivator Binding in the Retinoid X Receptor alpha Ligand Binding Domain.
ChainA
Resolution2.1 Å
3D
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K284 L294 Q297 V298 L301 R302 F450 E453 K40 L50 Q53 V54 L57 R58 F206 E209
BS02 9RA A I268 A272 L309 F313 R316 L326 C432 I24 A28 L65 F69 R72 L82 C188 PDBbind-CN: -logKd/Ki=6.20,Kd=0.629uM
BindingDB: EC50=33nM,Kd=36nM,Ki=379nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003707 nuclear steroid receptor activity
GO:0008270 zinc ion binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:4k6i, PDBe:4k6i, PDBj:4k6i
PDBsum4k6i
PubMed24187139
UniProtP19793|RXRA_HUMAN Retinoic acid receptor RXR-alpha (Gene Name=RXRA)

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