Structure of PDB 4jxf Chain A

Receptor sequence
>4jxfA (length=235) Species: 9606 (Homo sapiens) [Search protein sequence]
CIGEKIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGM
VQRVQNEVKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKN
RVKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIA
DFGLATQLKMPHESDVWSLGCMFYTLLIGRPPFVKNTLNKVVLADYEMPS
FLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMSR
3D structure
PDB4jxf Crystal Structure of PLK4 Kinase with an inhibitor: 400631
ChainA
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D136 T138 S140 N141 D154
Catalytic site (residue number reindexed from 1) D133 T135 S137 N138 D151
Enzyme Commision number 2.7.11.21: polo kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 631 A L18 G19 F23 V26 A39 K41 E90 M91 C92 G95 L143 A153 Q160 L15 G16 F20 V23 A36 K38 E87 M88 C89 G92 L140 A150 Q157
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4jxf, PDBe:4jxf, PDBj:4jxf
PDBsum4jxf
PubMed
UniProtO00444|PLK4_HUMAN Serine/threonine-protein kinase PLK4 (Gene Name=PLK4)

[Back to BioLiP]