Structure of PDB 4jwt Chain A

Receptor sequence
>4jwtA (length=245) Species: 326298 (Sulfurimonas denitrificans DSM 1251) [Search protein sequence]
GVDLGTENLYFQSMKIAIMGAMPEEISPILEKIGSYKSTSYAGNKYYEAT
YQGVELVIAYSKIGKVFSALSAATMIEHFGATKLLFSGVAGAISTNLKVG
DLIVATKLSQHDLDITAFGHPYGYVPEGSVFVEADKDMIELSKKVALEMG
KSVQEGIIATGDQFVANEERKNWIGTTFGADALEMEGGSVGVVCNALNIP
FFILRSISDAADMDASFSFDEFLESSAKESAEFIMKMVDELVALP
3D structure
PDB4jwt Crystal structure of a putative 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Sulfurimonas denitrificans DSM 1251
ChainA
Resolution2.05 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S14 A36 T37
Catalytic site (residue number reindexed from 1) S27 A49 T50
Enzyme Commision number 3.2.2.9: adenosylhomocysteine nucleosidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADE A A77 G78 F151 V152 L170 M172 S195 D196 A90 G91 F164 V165 L183 M185 S208 D209
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008782 adenosylhomocysteine nucleosidase activity
GO:0008930 methylthioadenosine nucleosidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0009086 methionine biosynthetic process
GO:0009116 nucleoside metabolic process
GO:0009164 nucleoside catabolic process
GO:0019284 L-methionine salvage from S-adenosylmethionine
GO:0019509 L-methionine salvage from methylthioadenosine
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:4jwt, PDBe:4jwt, PDBj:4jwt
PDBsum4jwt
PubMed
UniProtQ30QR2

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