Structure of PDB 4jwl Chain A

Receptor sequence
>4jwlA (length=194) Species: 9606 (Homo sapiens) [Search protein sequence]
HMSKTLQRNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKG
EGLNKTAIGDYLGEREELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRL
PGEAQKIDRMMEAFAQRYCLCNPGVFQSTDTCYVLSFAVIMLNTSLHNPN
VRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIRNEPFKIPE
3D structure
PDB4jwl Fragment-based identification of a locus in the Sec7 domain of Arno for the design of protein-protein interaction inhibitors
ChainA
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HRC A L148 L153 I193 F243 I245 L95 L100 I140 F190 I192 BindingDB: Kd=500000nM,Ki=3720000nM
Gene Ontology
Molecular Function
GO:0005085 guanyl-nucleotide exchange factor activity
Biological Process
GO:0032012 regulation of ARF protein signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:4jwl, PDBe:4jwl, PDBj:4jwl
PDBsum4jwl
PubMed24112024
UniProtQ99418|CYH2_HUMAN Cytohesin-2 (Gene Name=CYTH2)

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