Structure of PDB 4jwh Chain A

Receptor sequence
>4jwhA (length=185) Species: 284812 (Schizosaccharomyces pombe 972h-) [Search protein sequence]
RIRLGKVVPSSIRIVLDCAFDDLMNDKEINSLCQQVTRCHSANRTALHPV
ELFATNFGGRLKTRQDFVLKGQQNNWKRYNPTTKSYLEEFESQKEKLVYL
SADSDNTITELDEDKIYIIGAIVDKNRYKNLCQNKASEQGIKTAKLPIDE
YIKKILTVNQVFEILSLWLEYRDWEKAFMEVIPKR
3D structure
PDB4jwh Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate.
ChainA
Resolution2.04 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.1.1.221: tRNA (guanine(9)-N(1))-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A L183 S184 A185 I202 G203 D207 N209 Y211 L214 C215 K228 L229 I242 L243 V248 L100 S101 A102 I119 G120 D124 N126 Y128 L131 C132 K145 L146 I155 L156 V161
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0008168 methyltransferase activity
GO:0052905 tRNA (guanosine(9)-N1)-methyltransferase activity
Biological Process
GO:0002939 tRNA N1-guanine methylation
GO:0008033 tRNA processing
GO:0032259 methylation
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4jwh, PDBe:4jwh, PDBj:4jwh
PDBsum4jwh
PubMed24081582
UniProtO14214|TRM10_SCHPO tRNA (guanine(9)-N1)-methyltransferase (Gene Name=trm10)

[Back to BioLiP]