Structure of PDB 4jve Chain A

Receptor sequence
>4jveA (length=92) Species: 9606 (Homo sapiens) [Search protein sequence]
QIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLY
DEKQQHIVYCSNDLLGDLGVPSFSVKEHRKIYTMIYRNLVVV
3D structure
PDB4jve Rational Design and Binding Mode Duality of MDM2-p53 Inhibitors.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1MQ A L54 F55 L57 G58 Q59 I61 M62 I99 L37 F38 L40 G41 Q42 I44 M45 I81 MOAD: ic50=0.086uM
PDBbind-CN: -logKd/Ki=7.07,IC50=0.086uM
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4jve, PDBe:4jve, PDBj:4jve
PDBsum4jve
PubMed23597064
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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