Structure of PDB 4jv7 Chain A

Receptor sequence
>4jv7A (length=85) Species: 9606 (Homo sapiens) [Search protein sequence]
TLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIV
YCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVV
3D structure
PDB4jv7 Rational Design and Binding Mode Duality of MDM2-p53 Inhibitors.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1MN A L54 F55 L57 G58 Q59 I61 M62 V93 I99 L29 F30 L32 G33 Q34 I36 M37 V68 I74 MOAD: ic50=1uM
PDBbind-CN: -logKd/Ki=6.00,IC50=1.0uM
BindingDB: IC50=2000nM
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:4jv7, PDBe:4jv7, PDBj:4jv7
PDBsum4jv7
PubMed23597064
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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