Structure of PDB 4js9 Chain A

Receptor sequence
>4js9A (length=405) Species: 10090 (Mus musculus) [Search protein sequence]
QYVRIKNWGSGEILHDTLHHKATSSIMNPKSLTRGPRDKPTPLEELLPHA
IEFINQYYGSFKEAKIEEHLARLEAVTKEIETTGTYQLTLDELIFATKMA
WRNAPRCIGRIQWSNLQVFDARNCSTAQEMFQHICRHILYATNNGNIRSA
ITVFPQRSDGKHDFRLWNSQLIRYAGYQMPTIRGDAATLEFTQLCIDLGW
KPRYGRFDVLPLVLQADGQDPEVFEIPPDLVLEVTMEHPKYEWFQELGLK
WYALPAVANMLLEVGGLEFPACPFNGWYMGTEIGVRDFCDTQRYNILEEV
GRRMGLETHTLASLWKDRAVTEINVAVLHSFQKQNVTIMDHHTASESFMK
HMQNEYRARGGCPADWIWLVPPVSGSITPVFHQEMLNYVLSPFYYYQIEP
WKTHI
3D structure
PDB4js9 Kinetic and Structural Characterization of Inducible Nitric Oxide Synthase Substituted With Mesoheme
ChainA
Resolution2.784 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) C194 R197 W366 E371
Catalytic site (residue number reindexed from 1) C107 R110 W277 E282
Enzyme Commision number 1.14.13.39: nitric-oxide synthase (NADPH).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MH0 A W188 C194 M349 F363 G365 W366 E371 W457 Y485 W101 C107 M260 F274 G276 W277 E282 W368 Y396
BS02 H4B A S112 M114 R375 I456 W457 S25 M27 R286 I367 W368
Gene Ontology
Molecular Function
GO:0004517 nitric-oxide synthase activity
Biological Process
GO:0006809 nitric oxide biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4js9, PDBe:4js9, PDBj:4js9
PDBsum4js9
PubMed
UniProtP29477|NOS2_MOUSE Nitric oxide synthase, inducible (Gene Name=Nos2)

[Back to BioLiP]