Structure of PDB 4js8 Chain A

Receptor sequence
>4js8A (length=261) Species: 9606 (Homo sapiens) [Search protein sequence]
NECISVKGRIYSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQT
LDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVMECGNIDLNSWLK
KKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGMLKLID
FGIANQMQPDTVGTVNYMPPEAIKDMSKISPKSDVWSLGCILYYMTYGKT
PFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISI
PELLAHPYVQI
3D structure
PDB4js8 Crystal structure of TTK kinase domain with an inhibitor: 401348
ChainA
Resolution1.94 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D647 K649 N652 D664 D674 T686
Catalytic site (residue number reindexed from 1) D133 K135 N138 D150 D160 T164
Enzyme Commision number 2.7.12.1: dual-specificity kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1PF A I531 A551 I586 M602 E603 G605 I607 D608 L654 I663 P673 T675 I17 A37 I72 M88 E89 G91 I93 D94 L140 I149 P159 T161
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4js8, PDBe:4js8, PDBj:4js8
PDBsum4js8
PubMed
UniProtP33981|TTK_HUMAN Dual specificity protein kinase TTK (Gene Name=TTK)

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