Structure of PDB 4js5 Chain A

Receptor sequence
>4js5A (length=464) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
QSTFLFHDYETFGTHPALDRPAQFAAIRTDSEFNVIGEPEVFYCKPADDY
LPQPGAVLITGITPQEARAKGENEAAFAARIHSLFTVPKTCILGYNNVRF
DDEVTRNIFYRNFYDPYAWSWQHDNSRWDLLDVMRACYALRPEGINWPEN
DDGLPSFRLEHLTKANGIEHSNAHDAMADVYATIAMAKLVKTRQPRLFDY
LFTHRNKHKLMALIDVPQMKPLVHVSGMFGAWRGNTSWVAPLAWHPENRN
AVIMVDLAGDISPLLELDSDTLRERLYTAKTDLGDNAAVPVKLVHINKCP
VLAQANTLRPEDADRLGINRQHCLDNLKILRENPQVREKVVAIFAEAPSD
NVDAQLYNGFFSDADRAAMKIVLETEPRNLPALDITFVDKRIEKLLFNYR
ARNFPGTLDYAEQQRWLEHRRQVFTPEFLQGYADELQMLVQQYADDKEKV
ALLKALWQYAEEIV
3D structure
PDB4js5 Crystal structures of Escherichia coli exonuclease I in complex with single-stranded DNA provide insights into the mechanism of processive digestion.
ChainA
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.11.1: exodeoxyribonuclease I.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A D15 Y16 E17 T18 T67 N103 F107 Y124 R142 F164 R165 H181 G234 M235 G237 A238 N255 N257 L283 Y284 A286 K287 N304 Y368 F371 D8 Y9 E10 T11 T60 N96 F100 Y117 R135 F157 R158 H174 G227 M228 G230 A231 N248 N250 L276 Y277 A279 K280 N297 Y357 F360
Gene Ontology
Molecular Function
GO:0000175 3'-5'-RNA exonuclease activity
GO:0000287 magnesium ion binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003697 single-stranded DNA binding
GO:0004527 exonuclease activity
GO:0004529 DNA exonuclease activity
GO:0005515 protein binding
GO:0008310 single-stranded DNA 3'-5' DNA exonuclease activity
GO:0046872 metal ion binding
GO:0051575 5'-deoxyribose-5-phosphate lyase activity
Biological Process
GO:0006259 DNA metabolic process
GO:0006274 DNA replication termination
GO:0006281 DNA repair
GO:0006308 DNA catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4js5, PDBe:4js5, PDBj:4js5
PDBsum4js5
PubMed23609540
UniProtP04995|EX1_ECOLI Exodeoxyribonuclease I (Gene Name=sbcB)

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