Structure of PDB 4js1 Chain A

Receptor sequence
>4js1A (length=318) Species: 9606 (Homo sapiens) [Search protein sequence]
PEASFQVWNKDSSSKNLIPRLQKIWKNYLSMNKYKVSYKGPGPGIKFSAE
ALRCHLRDHVNVSMVEVTDFPFNTSEWEGYLPKESIRTKAGPWGRCAVVS
SAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMNSQLVT
TEKRFLKDSLYNEGILIVWDPSVYHSDIPKWYQNPDYNFFNNYKTYRKLH
PNQPFYILKPQMPWELWDILQEISPEEIQPNPPSSGMLGIIIMMTLCDQV
DIYEFLPSKRKTDVCYYYQKFFDSACTMGAYHPLLYEKNLVKHLNQGTDE
DIYLLGKATLPGFRTIHC
3D structure
PDB4js1 The structure of human alpha-2,6-sialyltransferase reveals the binding mode of complex glycans.
ChainA
Resolution2.09 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) P320 H370
Catalytic site (residue number reindexed from 1) P232 H282
Enzyme Commision number 2.4.3.1: beta-galactoside alpha-(2,6)-sialyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CTN A S189 A190 F211 S322 G324 F343 C353 C364 K376 S101 A102 F123 S234 G236 F255 C265 C276 K288
BS02 PO4 A N212 S322 S323 H370 N124 S234 S235 H282
Gene Ontology
Molecular Function
GO:0008373 sialyltransferase activity
Biological Process
GO:0006486 protein glycosylation

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:4js1, PDBe:4js1, PDBj:4js1
PDBsum4js1
PubMed23999306
UniProtP15907|SIAT1_HUMAN Beta-galactoside alpha-2,6-sialyltransferase 1 (Gene Name=ST6GAL1)

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