Structure of PDB 4jrn Chain A

Receptor sequence
>4jrnA (length=349) Species: 5811 (Toxoplasma gondii) [Search protein sequence]
SELVFEKADSGCVIGKRILAHMQELENSERLDRILTVAAWPPDVPKRFVS
VTTGETRTLVRGAPLGSGGFATVYEATDVETNEELAVKVFMSEKEPTDET
MLDLQRESSCYRNFSLAKTAKDAQESCRFMVPSDVVMLEGQPASTEVVIG
LTTRWVPNYFLLMMRAEADMSKVISWVFGDASVNKSEFGLVVRMYLSSQA
IKLVANVQAQGIVHTDIKPANFLLLKDGRLFLGDFGTYRINNSVGRGTPG
YEPPERPGITYTFPTDAWQLGITLYCIWCKERPTPADGIWDYLHFADCPS
TPELVQDLIRSLLNRDPQKRMLPLQALETAAFKEMDSVVKGAAQNFEQQ
3D structure
PDB4jrn Structure of the Toxoplasma gondii ROP18 kinase domain reveals a second ligand binding pocket required for acute virulence.
ChainA
Resolution2.71 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLC A N220 R347 N27 R154
BS02 FRU A S260 G262 T265 M284 S285 S67 G69 T72 M91 S92
BS03 ANP A G259 G261 G262 A264 V266 K281 A359 D427 G66 G68 G69 A71 V73 K88 A166 D234
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4jrn, PDBe:4jrn, PDBj:4jrn
PDBsum4jrn
PubMed24129568
UniProtQ2PAY2

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