Structure of PDB 4jr2 Chain A

Receptor sequence
>4jr2A (length=224) Species: 9606 (Homo sapiens) [Search protein sequence]
ATYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLG
FDVIVYNDCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDG
VTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGKIPVEADFLFAYSTVPG
YYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSD
DPHFHEKKQIPCVVSMLTKELYFS
3D structure
PDB4jr2 Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation.
ChainA
Resolution1.65 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G85 V86 H144 G145 C186
Catalytic site (residue number reindexed from 1) G30 V31 H89 G90 C131
Enzyme Commision number 3.4.22.60: caspase-7.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R87 S143 H144 Q184 C186 Y230 S231 W232 R233 P235 S275 Q276 R32 S88 H89 Q129 C131 Y152 S153 W154 R155 P157 S197 Q198
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:4jr2, PDBe:4jr2, PDBj:4jr2
PDBsum4jr2
PubMed23650375
UniProtP55210|CASP7_HUMAN Caspase-7 (Gene Name=CASP7)

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