Structure of PDB 4jr0 Chain A

Receptor sequence
>4jr0A (length=226) Species: 9606 (Homo sapiens) [Search protein sequence]
ADNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLK
YEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNG
PVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTKIPVEADFLYAYSTAP
GYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFS
FDATFHAKKQIPCIVSMLTKELYFYH
3D structure
PDB4jr0 Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation.
ChainA
Resolution1.796 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) T62 S63 H121 G122 C163 R164
Catalytic site (residue number reindexed from 1) T30 S31 H89 G90 C131 R132
Enzyme Commision number 3.4.22.56: caspase-3.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R64 H121 Q161 C163 S205 W206 R207 N208 S209 S249 F250 R32 H89 Q129 C131 S154 W155 R156 N157 S158 S198 F199
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4jr0, PDBe:4jr0, PDBj:4jr0
PDBsum4jr0
PubMed23650375
UniProtP42574|CASP3_HUMAN Caspase-3 (Gene Name=CASP3)

[Back to BioLiP]