Structure of PDB 4jmy Chain A

Receptor sequence

>4jmyA (length=182) Species: 40271 (Hepatitis C virus genotype 2) [Search protein sequence]

APITAYSQQTRGLLGCIITSLTGRDKNQVDGEVQVLSTATQSFLATCVNG
VCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWPAPPGARSMTPCTCG
SSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHV
VGIFRAAVCTRGVAKAVDFIPVESMETTMRAS

3D structure

PDB

4jmy Importance of the peptide scaffold of drugs that target the hepatitis C virus NS3 protease and its crucial bioactive conformation and dynamic factors.

Chain

Resolution

1.95 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	H57 D81 G137 S139
Catalytic site (residue number reindexed from 1)	H57 D81 G137 S139
Enzyme Commision number	3.4.21.98: hepacivirin. 3.6.1.15: nucleoside-triphosphate phosphatase. 3.6.4.13: RNA helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	A	T4 A5 Y6 S7 Q8 T10 R11 C16 S20 Q28 D30 G31 E32 V33 Q34 V35 L36 S37 K62 T63 L64 A65 R92 M94	T4 A5 Y6 S7 Q8 T10 R11 C16 S20 Q28 D30 G31 E32 V33 Q34 V35 L36 S37 K62 T63 L64 A65 R92 M94
BS02	peptide	A	H57 L135 G137 S139 F154 R155 A156 A157 V158 C159	H57 L135 G137 S139 F154 R155 A156 A157 V158 C159
BS03	ZN	A	C97 C99 C145	C97 C99 C145

Gene Ontology

	Molecular Function
GO:0008236	serine-type peptidase activity

	Biological Process
GO:0006508	proteolysis
GO:0019087	transformation of host cell by virus

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:4jmy, PDBe:4jmy, PDBj:4jmy
PDBsum	4jmy
PubMed
UniProt	Q81817

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