Structure of PDB 4jlz Chain A

Receptor sequence
>4jlzA (length=363) Species: 9823 (Sus scrofa) [Search protein sequence]
GAWKLQTVLEKVRLSRHEISEAAEVVNWVVEHLLRRLQGGESEFKGVALL
RTGSYYERVKISAPNEFDVMFKLEVPRIQLEEYCNSGAHYFVKFKRNPGG
NPLEQFLEKEILSASKMLSKFRKIIKEEIKNIEDTGVTVERKRRGSPAVT
LLISKPKEISVDIILALESKSSWPASTQKGLPISQWLGAKVKNNLKRQPF
YLVPKHAKEGSGFQEETWRLSFSHIEKDILKNHGQSKTCCEIDGVKCCRK
ECLKLMKYLLEQLKKKFGNRRELAKFCSYHVKTAFFHVCTQDPHDNQWHL
KNLECCFDNCVAYFLQCLKTEQLANYFIPGVNLFSRDLIDKPSKEFLSKQ
IEYERNNGFPVFW
3D structure
PDB4jlz Structural mechanism of cytosolic DNA sensing by cGAS
ChainA
Resolution2.27 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.86: cyclic GMP-AMP synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H367 C373 C374 C381 H233 C239 C240 C247
BS02 UTP A G187 S188 D202 R353 S412 Y413 G53 S54 D68 R219 S278 Y279
External links
PDB RCSB:4jlz, PDBe:4jlz, PDBj:4jlz
PDBsum4jlz
PubMed23722159
UniProtI3LM39|CGAS_PIG Cyclic GMP-AMP synthase (Gene Name=CGAS)

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