Structure of PDB 4jlh Chain A

Receptor sequence
>4jlhA (length=140) Species: 11698 (Human immunodeficiency virus type 1 (NEW YORK-5 ISOLATE)) [Search protein sequence]
CSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLA
GRWPVKTVHTDNGSNFTSTTVKTACWWAGIKQEFESMNKELKKIIGQVRD
QAEHLKTAVQMAVFIHNKKRKGGGYSAGERIVDIIATDIQ
3D structure
PDB4jlh The A128T Resistance Mutation Reveals Aberrant Protein Multimerization as the Primary Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors.
ChainA
Resolution2.09 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0L9 A Q95 T125 T128 A129 W132 Q40 T70 T73 A74 W77 MOAD: ic50=15.6uM
PDBbind-CN: -logKd/Ki=5.40,IC50=4.0uM
BindingDB: IC50=4e+2nM
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
Biological Process
GO:0015074 DNA integration

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Molecular Function
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Biological Process
External links
PDB RCSB:4jlh, PDBe:4jlh, PDBj:4jlh
PDBsum4jlh
PubMed23615903
UniProtP12497|POL_HV1N5 Gag-Pol polyprotein (Gene Name=gag-pol)

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