Structure of PDB 4jlc Chain A

Receptor sequence
>4jlcA (length=646) Species: 10090 (Mus musculus) [Search protein sequence]
ICQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPV
DVQMREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLE
EPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDG
QSVYKLTDFGAARELEDDGTEEYLHPDMYERAVLRKDHQKKYGATVDLWS
VGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGP
IDWSGDMPLSCSLSQGLQALLTPVLANILEADQEKCWGFDQFFAETSDVL
HRMVIHVFSLQHMTAHKIYIHSYNTAAVFHELVYKQTKIVSSNQELIYEG
RRLVLELGRLAQHFPKTTEENPIFVTSREQLNTVGLRYEKISLPKIHPRY
DLDGDASMAKAVTGVVCYACRTASTLLLYQELMRKGVRWLVELVKDDYNE
TVHKKTEVVITLDFCIRNIEKTVKVYEKLMKVNELGEISDIHTKLLRLSS
SQGTIESSLQDISSRLSPGGLLADTWAHQEGTHPRDRNVEKLQVLLNCIT
EIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMSHFSEECVRKYE
AFKDKSEEWMRKMLHLRKQLLSLTNQCFDIEEEVSKYQDYTNELQE
3D structure
PDB4jlc Structural Insights into the Functions of TBK1 in Innate Antimicrobial Immunity.
ChainA
Resolution3.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D135 K137 N140 D157 T176
Catalytic site (residue number reindexed from 1) D136 K138 N141 D158 T170
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SU6 A L15 G16 A36 M86 E87 F88 C89 P90 G92 T96 M142 T156 L16 G17 A37 M87 E88 F89 C90 P91 G93 T97 M143 T157
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0019903 protein phosphatase binding
GO:0042802 identical protein binding
GO:0044024 histone H2AS1 kinase activity
GO:0051219 phosphoprotein binding
GO:0106310 protein serine kinase activity
Biological Process
GO:0002218 activation of innate immune response
GO:0002753 cytoplasmic pattern recognition receptor signaling pathway
GO:0006338 chromatin remodeling
GO:0006468 protein phosphorylation
GO:0010468 regulation of gene expression
GO:0010508 positive regulation of autophagy
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0016239 positive regulation of macroautophagy
GO:0016310 phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0032479 regulation of type I interferon production
GO:0032481 positive regulation of type I interferon production
GO:0032727 positive regulation of interferon-alpha production
GO:0032728 positive regulation of interferon-beta production
GO:0034142 toll-like receptor 4 signaling pathway
GO:0043123 positive regulation of canonical NF-kappaB signal transduction
GO:0044565 dendritic cell proliferation
GO:0045087 innate immune response
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0050830 defense response to Gram-positive bacterium
GO:0051607 defense response to virus
GO:0060340 positive regulation of type I interferon-mediated signaling pathway
GO:0140374 antiviral innate immune response
GO:1904262 negative regulation of TORC1 signaling
GO:1904263 positive regulation of TORC1 signaling
GO:1904417 positive regulation of xenophagy
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4jlc, PDBe:4jlc, PDBj:4jlc
PDBsum4jlc
PubMed23746807
UniProtQ9WUN2|TBK1_MOUSE Serine/threonine-protein kinase TBK1 (Gene Name=Tbk1)

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