Structure of PDB 4jjf Chain A

Receptor sequence
>4jjfA (length=344) Species: 79929 (Methanothermobacter marburgensis str. Marburg) [Search protein sequence]
MKLAILGAGCYRTHAASGITNFSRACEVAEMVGKPEIAMTHSTITMGAEL
KELAGVDEVVVADPVFDNQFTVIDDFAYEDVIEAHKEDPEKIMPQIREKV
NEVAKELPKPPEGAIHFTHPEDLGFEITTDDREAVADADFIMTWFPKGDM
QPDIINKFIDDIKPGAIVTHACTIPTTKFYKIFEQKHGDLVTKPETLNVT
SYHPGAVPEMKGQVYIAEGYASEDAIETLFELGQKARGNAYRLPAELLGP
VCDMCSALTAITYAGILSYRDSVTQVLGAPASFAQMMAKESLEQITALME
KVGIDKMEENLDPGALLGTADSMNFGASAEILPTVFEILEKRKK
3D structure
PDB4jjf Crystal structures of [fe]-hydrogenase in complex with inhibitory isocyanides: implications for the h2 -activation site.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.12.98.2: 5,10-methenyltetrahydromethanopterin hydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FE9 A G7 G9 A62 D63 P64 P110 P111 D131 W144 F145 P146 I154 C172 A206 V207 G7 G9 A62 D63 P64 P110 P111 D131 W144 F145 P146 I154 C172 A206 V207 PDBbind-CN: -logKd/Ki=8.00,Ki=10nM
BS02 N2I A C172 G205 A206 C252 C172 G205 A206 C252 MOAD: Ki=10nM
PDBbind-CN: -logKd/Ki=8.00,Ki=10nM
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0047068 N5,N10-methenyltetrahydromethanopterin hydrogenase activity
Biological Process
GO:0006730 one-carbon metabolic process
GO:0015948 methanogenesis
GO:0019386 methanogenesis, from carbon dioxide

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4jjf, PDBe:4jjf, PDBj:4jjf
PDBsum4jjf
PubMed23873755
UniProtP32440|HMD_METTM 5,10-methenyltetrahydromethanopterin hydrogenase (Gene Name=hmd)

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