Structure of PDB 4jgv Chain A

Receptor sequence
>4jgvA (length=233) Species: 9606 (Homo sapiens) [Search protein sequence]
ANLLTSLVRAHLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLS
GSLEVIRKWAEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGK
LIFCSGLVLHRLQCARGFGDWIDSILAFSRSLHSLLVDVPAFACLSALVL
ITDRHGLQEPRRVEELQNRIASCLKEHVAAVAEPPALSRLLGKLPELRTL
CTQGLQRIFYLKLEDLVPPPPIIDKIFMDTLPF
3D structure
PDB4jgv Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway.
ChainA
Resolution3.01 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 T94 A L509 V510 T513 Q528 L555 K558 L148 V149 T152 Q167 L190 K193 PDBbind-CN: -logKd/Ki=6.57,Kd=0.27uM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4jgv, PDBe:4jgv, PDBj:4jgv
PDBsum4jgv
PubMed24316735
UniProtP22736|NR4A1_HUMAN Nuclear receptor subfamily 4immunitygroup A member 1 (Gene Name=NR4A1)

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