Structure of PDB 4jgt Chain A

Receptor sequence
>4jgtA (length=280) Species: 9606 (Homo sapiens) [Search protein sequence]
SHVSAQWVAEALRAPRAGQPLQLLDASWYLPKLGRDARREFEERHIPGAA
FFDIDQCSDRTSPYDHMLPGAEHFAEYAGRLGVGAATHVVIYDASDQGLY
SAPRVWWMFRAFGHHAVSLLDGGLRHWLRQNLPLSSGKSQPAPAEFRAQL
DPAFIKTYEDIKENLESRRFQVVDSRATGRFRGTEPEPRDGIEPGHIPGT
VNIPFTDFLSQEGLEKSPEEIRHLFQEKKVDLSKPLVATCGSGVTACHVA
LGAYLCGKPDVPIYDGSWVEWYMRARPEDV
3D structure
PDB4jgt Structure and Kinetic Analysis of H2S Production by Human Mercaptopyruvate Sulfurtransferase.
ChainA
Resolution2.161 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D63 H74 R188 C248 G249 S250 G251 V252 T253 A254 S275
Catalytic site (residue number reindexed from 1) D55 H66 R180 C240 G241 S242 G243 V244 T245 A246 S267
Enzyme Commision number 2.8.1.2: 3-mercaptopyruvate sulfurtransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PYR A W36 L38 R188 R197 C248 G249 S250 W28 L30 R180 R189 C240 G241 S242
Gene Ontology
Molecular Function
GO:0004792 thiosulfate sulfurtransferase activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0016783 sulfurtransferase activity
GO:0016784 3-mercaptopyruvate sulfurtransferase activity
GO:0042802 identical protein binding
Biological Process
GO:0000098 sulfur amino acid catabolic process
GO:0001822 kidney development
GO:0001889 liver development
GO:0009440 cyanate catabolic process
GO:0009636 response to toxic substance
GO:0019346 transsulfuration
GO:0021510 spinal cord development
GO:0070814 hydrogen sulfide biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0043005 neuron projection
GO:0045202 synapse
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4jgt, PDBe:4jgt, PDBj:4jgt
PDBsum4jgt
PubMed23698001
UniProtP25325|THTM_HUMAN 3-mercaptopyruvate sulfurtransferase (Gene Name=MPST)

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