Structure of PDB 4jg8 Chain A

Receptor sequence
>4jg8A (length=300) Species: 9606 (Homo sapiens) [Search protein sequence]
SIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEI
EILLRYGQHPNIITLKDVYDDGKYVYVVMELMKGGELLDKILRQKFFSER
EASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGF
AKQLRAENGLLMTPCYTANFVAPEVLERQGYDAACDIWSLGVLLYTMLTG
YTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDP
HQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQ
3D structure
PDB4jg8 Electrophilic fragment-based design of reversible covalent kinase inhibitors.
ChainA
Resolution3.1002 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D539 K541 N544 D561 T581
Catalytic site (residue number reindexed from 1) D125 K127 N130 D147 T167
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1LE A I428 C436 A449 K451 M493 L495 M496 D561 I14 C22 A35 K37 M79 L81 M82 D147 PDBbind-CN: -logKd/Ki=8.60,IC50<2.5nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4jg8, PDBe:4jg8, PDBj:4jg8
PDBsum4jg8
PubMed23540679
UniProtP51812|KS6A3_HUMAN Ribosomal protein S6 kinase alpha-3 (Gene Name=RPS6KA3)

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