Structure of PDB 4jg6 Chain A

Receptor sequence
>4jg6A (length=302) Species: 9606 (Homo sapiens) [Search protein sequence]
SIVQQLHRNSIQFTDGYEVKEDISVCKRCIHKATNMEFAVKIIDKSKRDP
TEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKF
FSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRIC
DFGFAKQLRAENGLLMTPCYTANFVAPEVLERQGYDAACDIWSLGVLLYT
MLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKML
HVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSAL
NR
3D structure
PDB4jg6 Electrophilic fragment-based design of reversible covalent kinase inhibitors.
ChainA
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D539 K541 N544 D561 T581
Catalytic site (residue number reindexed from 1) D129 K131 N134 D151 T171
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1LB A C436 A449 M496 D561 C26 A39 M86 D151 PDBbind-CN: -logKd/Ki=6.44,IC50=0.36uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:4jg6, PDBe:4jg6, PDBj:4jg6
PDBsum4jg6
PubMed23540679
UniProtP51812|KS6A3_HUMAN Ribosomal protein S6 kinase alpha-3 (Gene Name=RPS6KA3)

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