Structure of PDB 4jfr Chain A

Receptor sequence
>4jfrA (length=336) Species: 216895 (Vibrio vulnificus CMCP6) [Search protein sequence]
NAMAFNLRNRNFLKLLDFSTKEIQFLIDLSADLKKAKYAGTEQKKLLGKN
IALIFEKASTRTRCAFEVAAFDQGAQVTYIGPSGSQIGDKESMKDTARVL
GRMYDGIQYRGFGQAIVEELGAFAGVPVWNGLTDEFHPTQILADFLTMLE
HSQGKALADIQFAYLGDARNNVGNSLMVGAAKMGMDIRLVGPQAYWPDEE
LVAACQAIAKQTGGKITLTENVAEGVQGCDFLYTDVWVSMGESPEAWDER
VALMKPYQVNMNVLKQTGNPNVKFMHCLPAFHNDETTIGKQVADKFGMKG
LEVTEEVFESEHSIVFDEAENRMHTIKAVMVATLGS
3D structure
PDB4jfr Crystal structures and kinetic properties of anabolic ornithine carbamoyltransferase from human pathogens Vibrio vulnificus and Bacillus anthracis
ChainA
Resolution2.17 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) R59 T60 D87 R108 H135 Q138 D233 C275 R320
Catalytic site (residue number reindexed from 1) R61 T62 D89 R110 H137 Q140 D235 C277 R322
Enzyme Commision number 2.1.3.3: ornithine carbamoyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CP A S57 T58 R59 T60 R108 H135 Q138 C275 R320 S59 T60 R61 T62 R110 H137 Q140 C277 R322
Gene Ontology
Molecular Function
GO:0004585 ornithine carbamoyltransferase activity
GO:0016597 amino acid binding
GO:0016740 transferase activity
GO:0016743 carboxyl- or carbamoyltransferase activity
Biological Process
GO:0006520 amino acid metabolic process
GO:0006526 L-arginine biosynthetic process
GO:0006591 ornithine metabolic process
GO:0019240 citrulline biosynthetic process
GO:0042450 arginine biosynthetic process via ornithine
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4jfr, PDBe:4jfr, PDBj:4jfr
PDBsum4jfr
PubMed
UniProtQ8DCF5|OTC_VIBVU Ornithine carbamoyltransferase (Gene Name=argF)

[Back to BioLiP]