Structure of PDB 4jfk Chain A

Receptor sequence
>4jfkA (length=128) Species: 9606 (Homo sapiens) [Search protein sequence]
GAPATVTEQGEDITSKKDRGVLKIVKRVGNGEETPMIGDKVYVHYKGKLS
NGKKFDSSHDRNEPFVFSLGKGQVIKAWDIGVATMKKGEICHLLCKPEYA
YGSAGSLPKIPSNATLFFEIELLDFKGE
3D structure
PDB4jfk Increasing the efficiency of ligands for FK506-binding protein 51 by conformational control.
ChainA
Resolution1.15 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y57 F67 D68 I87 Y113 F130
Catalytic site (residue number reindexed from 1) Y45 F55 D56 I75 Y101 F118
Enzyme Commision number 5.2.1.8: peptidylprolyl isomerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 JFK A Y57 F67 D68 F77 G84 Q85 V86 I87 W90 Y113 S118 L119 P120 K121 I122 F130 Y45 F55 D56 F65 G72 Q73 V74 I75 W78 Y101 S106 L107 P108 K109 I110 F118 MOAD: Kd=0.36uM
PDBbind-CN: -logKd/Ki=6.44,Kd=0.36uM
BindingDB: Ki=300nM,Kd=360nM
Gene Ontology
Molecular Function
GO:0003755 peptidyl-prolyl cis-trans isomerase activity

View graph for
Molecular Function
External links
PDB RCSB:4jfk, PDBe:4jfk, PDBj:4jfk
PDBsum4jfk
PubMed23647266
UniProtQ13451|FKBP5_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP5 (Gene Name=FKBP5)

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