Structure of PDB 4jew Chain A

Receptor sequence
>4jewA (length=397) Species: 99287 (Salmonella enterica subsp. enterica serovar Typhimurium str. LT2) [Search protein sequence]
TAITRATFDEVILPVYAPADFIPVKGKGSRVWDQQGKEYIDFAGGIAVTA
LGHCHPALVEALKSQGETLWHTSNVFTNEPALRLGRKLIDATFAERVLFM
NSGTEANETAFKLARHYACVRHSPFKTKIIAFHNAFHGRSLFTVSVGGQP
KYSDGFGPKPADIIHVPFNDLHAVKAVMDDHTCAVVVEPIQGEGGVQAAT
PEFLKGLRDLCDEHQALLVFDEVQCGMGRTGDLFAYMHYGVTPDILTSAK
ALGGGFPVSAMLTTQEIASAFGSTYGGNPLACAVAGATFDIINTPEVLQG
IHTKRQQFVQHLQAIDEQFDIFSDIRGMGLLIGAELKPKYKGRARDFLYA
GAEAGVMVLNAGADVMRFAPSLVVEEADIHEGMQRFAQAVGKVVALE
3D structure
PDB4jew Conformational transitions, ligand specificity and catalysis in N-acetylornithine aminotransferase: Implications on drug designing and rational enzyme engineering in omega aminotransferases.
ChainA
Resolution1.48 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) F141 E193 D226 Q229 K255 T284 R377
Catalytic site (residue number reindexed from 1) F136 E188 D221 Q224 K250 T274 R367
Enzyme Commision number 2.6.1.11: acetylornithine transaminase.
2.6.1.17: succinyldiaminopimelate transaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 P00 A G108 T109 F141 H142 R144 E193 E198 D226 V228 K255 G103 T104 F136 H137 R139 E188 E193 D221 V223 K250
BS02 TNF A K30 K32 W37 K25 K27 W32
Gene Ontology
Molecular Function
GO:0003992 N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GO:0008483 transaminase activity
GO:0009016 succinyldiaminopimelate transaminase activity
GO:0030170 pyridoxal phosphate binding
GO:0042802 identical protein binding
Biological Process
GO:0006520 amino acid metabolic process
GO:0006525 arginine metabolic process
GO:0006526 L-arginine biosynthetic process
GO:0009085 lysine biosynthetic process
GO:0009089 lysine biosynthetic process via diaminopimelate
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Cellular Component
External links
PDB RCSB:4jew, PDBe:4jew, PDBj:4jew
PDBsum4jew
PubMed
UniProtP40732|ARGD_SALTY Acetylornithine/succinyldiaminopimelate aminotransferase (Gene Name=argD)

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