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BioLiP

Structure of PDB 4jcj Chain A

Receptor sequence
>4jcjA (length=144) Species: 10090 (Mus musculus) [Search protein sequence]
ISLCVGCGNQIHDQYILRVSPDLEWHAACLKCAECNQYLDESCTCFVRDG
KTYCKRDYIRLYGIKCAKCSIGFSKNDFVMRARSKVYHIECFRCVACSRQ
LIPGDEFALREDGLFCRADHDDVMVVGEPTLMDEDERLITRLEN
3D structure
PDB4jcj A structural basis for the regulation of the LIM-homeodomain protein islet 1 (Isl1) by intra- and intermolecular interactions.
ChainA
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C17 C20 H39 C42 C4 C7 H26 C29
BS02 ZN A C45 C48 C67 D70 C32 C35 C54 D57
BS03 ZN A C79 C82 H101 C104 C66 C69 H88 C91
BS04 ZN A C107 C110 C129 D132 C94 C97 C116 D119
Gene Ontology
Molecular Function
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Biological Process
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048665 neuron fate specification

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Molecular Function
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Biological Process
External links
PDB RCSB:4jcj, PDBe:4jcj, PDBj:4jcj
PDBsum4jcj
PubMed23750000
UniProtP61372;
P70662|LDB1_MOUSE LIM domain-binding protein 1 (Gene Name=Ldb1)

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